Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 9/20 | 0.56 |
| ▸ | ALPL | P05186 | 2/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30762457 | 1.00 | CCR2 (0.56) | CCR2ALPLACLYCNR1PTGS2 | |
| SCHEMBL12560662 | 0.85 | CCR2 (0.68) | CCR2TRPV4L3MBTL1 | |
| SCHEMBL533050 | 0.80 | TRPV4 (0.50) | CCR2ALPLACLYCNR1TRPV4 | |
| SCHEMBL5097716 | 0.80 | CCR2 (0.49) | CCR2PTGS2 | |
| SCHEMBL11158206 | 0.80 | ALPL (0.45) | CCR2ALPLACLYCNR1TRPV4 | |
| SCHEMBL31239603 | 0.80 | MCL1 (0.56) | CCR2L3MBTL1 | |
| SCHEMBL4589791 | 0.80 | MCL1 (0.56) | CCR2L3MBTL1 | |
| SCHEMBL15352925 | 0.79 | TRPV4 (0.46) | CCR2ALPLACLYCNR1TRPV4 | |
| SCHEMBL31704457 | 0.78 | SMN1; SMN2 (0.55) | PTGS2 | |
| SCHEMBL1645034 | 0.78 | CA1 (0.47) | CCR2ALPLACLYCNR1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1963259-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |
| WO-2007068894-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |