Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.62 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.62 |
| ▸ | RXRA | P19793 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 2/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6024715 | 0.83 | NR1H2 (0.62) | NR1H2NR1H3RXRAPPARGTOP2A | |
| SCHEMBL1125582 | 0.83 | NR1H2 (0.62) | NR1H2NR1H3RXRAPPARGTOP2A | |
| SCHEMBL3357542 | 0.82 | IDO1 (0.42) | NR1H2NR1H3TOP2AMEN1KMT2A | |
| SCHEMBL4263730 | 0.80 | NR1H2 (0.60) | NR1H2NR1H3RXRAPPARGTOP2A | |
| SCHEMBL4260822 | 0.80 | NR1H2 (0.62) | NR1H2NR1H3RXRAPPARGTOP2A | |
| SCHEMBL4013652 | 0.79 | NR1H2 (0.95) | NR1H2NR1H3RXRA | |
| SCHEMBL4018368 | 0.79 | NR1H2 (0.55) | NR1H2NR1H3RXRAPPARGTOP2A | |
| SCHEMBL4011960 | 0.78 | ESR1 (0.41) | NR1H2NR1H3RXRAMEN1KMT2A | |
| SCHEMBL4013276 | 0.78 | NR1H2 (0.53) | NR1H2NR1H3PTGDR2MEN1KMT2A | |
| SCHEMBL16675083 | 0.78 | IDO1 (0.43) | NR1H2NR1H3TOP2ASYKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |