Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | LPL | P06858 | 2/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4160395 | 0.80 | NR1H2 (0.56) | NR1H2NR1H3 | |
| SCHEMBL4012984 | 0.79 | NR1H2 (0.62) | NR1H2NR1H3RXRAPPARGTOP2A | |
| SCHEMBL4013608 | 0.77 | NCF1 (0.44) | NR1H2NR1H3RXRANCF1PTGDR2 | |
| SCHEMBL22963781 | 0.77 | LPL (0.40) | LPLLIPG | |
| SCHEMBL31577388 | 0.77 | LPL (0.40) | LPLLIPG | |
| SCHEMBL6024715 | 0.76 | NR1H2 (0.62) | NR1H2NR1H3RXRAPPARGTOP2A | |
| SCHEMBL1125582 | 0.76 | NR1H2 (0.62) | NR1H2NR1H3RXRAPPARGTOP2A | |
| SCHEMBL24654432 | 0.76 | LIPG (0.56) | LPLLIPG | |
| SCHEMBL25681062 | 0.76 | LIPG (0.56) | LPLLIPG | |
| SCHEMBL30009475 | 0.76 | LIPG (0.56) | LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |