Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3357542 | 0.85 | IDO1 (0.42) | NR1H2NR1H3IDO1TDO2NUDT1 | |
| SCHEMBL28021043 | 0.82 | NR4A2 (0.56) | NR1H2NR1H3NR4A2SMN1; SMN2KDM4E | |
| SCHEMBL4016535 | 0.82 | PIK3CD (0.61) | NR1H2NR1H3NR4A2NUDT1PIK3CD | |
| SCHEMBL16675083 | 0.81 | IDO1 (0.43) | NR1H2NR1H3IDO1TDO2PIK3CD | |
| SCHEMBL25740852 | 0.79 | CYP2A6 (0.50) | NR4A2IDO1SMN1; SMN2MAPK14GCGR | |
| SCHEMBL4012984 | 0.78 | NR1H2 (0.62) | NR1H2NR1H3IDO1TDO2PIK3CD | |
| SCHEMBL27809134 | 0.75 | NR4A2 (0.51) | NR1H2NR1H3NR4A2PIK3CDSMN1; SMN2 | |
| SCHEMBL4012775 | 0.74 | NR1H2 (0.77) | NR1H2NR1H3NR4A2CYP2C9 | |
| SCHEMBL18695357 | 0.74 | CCR1 (0.50) | IDO1TDO2PIK3CDSMN1; SMN2KDM4E | |
| SCHEMBL4014159 | 0.73 | NR4A2 (0.61) | NR1H2NR1H3NR4A2SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |