Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016374 | 0.88 | F10 (0.40) | SMN1; SMN2CD274MAPK1GRM1KDM4E | |
| SCHEMBL4013362 | 0.84 | MAPK1 (0.37) | SMN1; SMN2MAPK1GRM1LMNAKDM4E | |
| SCHEMBL2844592 | 0.84 | ESR2 (0.43) | AGTR1 | |
| SCHEMBL4009996 | 0.83 | S1PR1 (0.37) | SMN1; SMN2CD274 | |
| SCHEMBL4313277 | 0.80 | CD274 (0.41) | CD274F10 | |
| SCHEMBL27792668 | 0.79 | LMNA (0.41) | SMN1; SMN2MAPK1LMNAKDM4E | |
| SCHEMBL4450943 | 0.79 | CYP3A4 (0.39) | CD274MAPK1GRM1KDM4EALDH1A1 | |
| SCHEMBL1892641 | 0.79 | APLNR (0.42) | — | |
| SCHEMBL4011164 | 0.79 | SLC33A1 (0.39) | TDP2 | |
| SCHEMBL1893086 | 0.78 | PPARG (0.45) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133970-A1 | CRYSTALLINE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-05 | — | — | WO | disclosed |
| EP-2074117-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008062905-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-29 | — | — | WO | disclosed |