Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 15/20 | 0.41 |
| ▸ | PPOX | P50336 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4018792 | 0.84 | CCR1 (0.47) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4016337 | 0.80 | CCR1 (0.37) | CCR1PPOXLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4021523 | 0.78 | CCR1 (0.43) | CCR1PPOXLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4019585 | 0.78 | CCR1 (0.43) | CCR1PPOXLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL3866250 | 0.76 | ALDH1A1 (0.35) | CCR1PPOXLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4565941 | 0.76 | CCR1 (0.55) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4019923 | 0.76 | PPOX (0.45) | PPOXLMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL4304679 | 0.76 | CCR1 (0.48) | CCR1CYP2C19KCNH2 | |
| SCHEMBL3465600 | 0.75 | CCR1 (0.73) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4020360 | 0.75 | CCR1 (0.47) | CCR1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |