SCHEMBL4019923

SCHEMBL4019923

COc1cc(N2CCN(C(Cl)C=O)CC2)c(F)cc1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPOX P50336 3/20 0.45
ALDH1A1 P00352 7/20 0.43
SMN1; SMN2 Q16637 5/20 0.43
LMNA P02545 4/20 0.43
TP53 P04637 1/20 0.43
TSHR P16473 1/20 0.43
HSD17B10 Q99714 1/20 0.43
HTT P42858 1/20 0.41
MAPT P10636 5/20 0.37
MAPK1 P28482 2/20 0.36
PKM P14618 2/20 0.36
HSP90AA1 P07900 1/20 0.36
RAB9A P51151 1/20 0.36
CCR6 P51684 1/20 0.36
CACNA1B Q00975 1/20 0.36
APBA1 Q02410 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
FFAR4 Q5NUL3 2/20 0.35
ALDH1A3 P47895 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3632434 0.82 PPOX (0.43) PPOXALDH1A1SMN1; SMN2LMNATP53
SCHEMBL3726336 0.82 PPOX (0.43) PPOXALDH1A1SMN1; SMN2LMNATP53
SCHEMBL2353510 0.77 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2LMNAMAPT
SCHEMBL4016337 0.77 CCR1 (0.37) PPOXALDH1A1SMN1; SMN2LMNATP53
SCHEMBL4013750 0.76 CCR1 (0.41) PPOXALDH1A1SMN1; SMN2LMNATP53
SCHEMBL17543889 0.76 PPOX (0.54) PPOXALDH1A1SMN1; SMN2LMNATP53
SCHEMBL4018792 0.75 CCR1 (0.47)
SCHEMBL4019585 0.75 CCR1 (0.43) PPOXALDH1A1SMN1; SMN2LMNATP53
SCHEMBL4021523 0.75 CCR1 (0.43) PPOXALDH1A1SMN1; SMN2LMNATP53
SCHEMBL1639662 0.74 HTR3E (0.56) PPOXALDH1A1LMNAMAPTSUV39H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1691810-A4 SUBSTITUTED PIPERAZINES CHEMOCENTRYX INC (US) 2009-07-01 EP disclosed
EP-1691810-A1 SUBSTITUTED PIPERAZINES ChemoCentryx Inc (US) 2006-08-23 EP disclosed
WO-2005056015-A1 SUBSTITUTED PIPERAZINES CHEMOCENTRYX, INC. (US) 2005-06-23 WO disclosed