Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 3/20 | 0.38 |
| ▸ | CLK1 | P49759 | 3/20 | 0.38 |
| ▸ | CLK3 | P49761 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014357 | 0.71 | CSNK1E (0.42) | CSNK1ECLK1CLK3DYRK1ADYRK1B | |
| SCHEMBL4016027 | 0.69 | CLK1 (0.74) | CSNK1ECLK1CLK3DYRK1ADYRK1B | |
| SCHEMBL2170658 | 0.69 | DYRK1A (0.61) | CSNK1ECLK1CLK3DYRK1ADYRK1B | |
| SCHEMBL29214090 | 0.68 | NOX1 (0.53) | CSNK1ECLK1CLK3DYRK1ADYRK1B | |
| SCHEMBL27719126 | 0.67 | ADRA2A (0.55) | MAPTHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL20525389 | 0.64 | LMNA (0.65) | MAPTMEN1KMT2ALMNAAPOBEC3A | |
| SCHEMBL11032742 | 0.61 | CYP19A1 (0.42) | CSNK1ECLK1CLK3DYRK1ADYRK1B | |
| SCHEMBL13750429 | 0.59 | LMNA (0.45) | CSNK1ECLK1CLK3DYRK1ADYRK1B | |
| SCHEMBL13750346 | 0.58 | BCHE (0.52) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL8038654 | 0.58 | CLK1 (0.54) | CSNK1ECLK1CLK3DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |