Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007502 | 0.97 | SMN1; SMN2 (0.50) | SMN1; SMN2ESR1FPR2KMT2AKDM4E | |
| SCHEMBL4009094 | 0.95 | SMN1; SMN2 (0.49) | SMN1; SMN2ESR1FPR2KMT2AKDM4E | |
| SCHEMBL4008767 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2ESR1FPR2KMT2AALDH1A1 | |
| SCHEMBL697680 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2ESR1FPR2KMT2AALDH1A1 | |
| SCHEMBL698417 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2ESR1FPR2KMT2AALDH1A1 | |
| SCHEMBL1573152 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2ESR1FPR2KMT2AALDH1A1 | |
| SCHEMBL1573428 | 0.81 | APAF1 (0.42) | SMN1; SMN2FPR2KMT2AADRA2AADRA2B | |
| SCHEMBL696323 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2FPR2KMT2AADRA2AADRA2B | |
| SCHEMBL698793 | 0.80 | KMT2A (0.50) | KMT2AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL698574 | 0.80 | KMT2A (0.50) | KMT2AADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547718-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-16 | — | — | US | claimed |