Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3643414 | 0.80 | BUB1 (0.34) | BUB1ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL459319 | 0.79 | CA12 (0.41) | ALDH1A1KDM4ENPC1HPGDTSHR | |
| SCHEMBL4012576 | 0.78 | ADRB2 (0.46) | ALDH1A1KDM4ELMNATSHRHIF1A | |
| SCHEMBL1853295 | 0.71 | KDM4C (0.52) | ALDH1A1KDM4EMAPTTHRB | |
| SCHEMBL3339535 | 0.71 | MEN1 (0.42) | MELKALDH1A1KDM4ELMNATSHR | |
| SCHEMBL4069875 | 0.70 | ALDH1A1 (0.40) | MELKALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL23934639 | 0.70 | AOC1 (0.41) | MELKALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL4057138 | 0.70 | SIRT3 (0.36) | BUB1ALDH1A1KDM4EMAPTAOC1 | |
| SCHEMBL16671024 | 0.70 | CYP2E1 (0.41) | LMNAAOC1AOC3 | |
| SCHEMBL17318487 | 0.69 | CA12 (0.45) | ALDH1A1TSHRGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074114-A1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008143759-A1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |