Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 8/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.40 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4010967 | 0.85 | NR1H2 (0.53) | NR1H2NR1H3RXRAPDE4APDE4C | |
| SCHEMBL2379509 | 0.78 | SLC40A1 (0.40) | PDE4APDE4CPDE4D | |
| SCHEMBL4018341 | 0.78 | NR1H2 (0.77) | NR1H2NR1H3RXRA | |
| SCHEMBL4017522 | 0.76 | NR1H2 (0.45) | NR1H2NR1H3RXRAPDE4APDE4C | |
| SCHEMBL16012054 | 0.75 | MAPK14 (0.45) | NR1H2NR1H3RXRA | |
| SCHEMBL4018578 | 0.74 | PTGDR2 (0.41) | NR1H2NR1H3RXRAPDE4APDE4C | |
| SCHEMBL4016970 | 0.74 | NR1H3 (0.50) | NR1H2NR1H3RXRAPDE4APDE4C | |
| SCHEMBL13416088 | 0.74 | CA1 (0.45) | PDE4APDE4CPDE4D | |
| SCHEMBL16211223 | 0.74 | PDE4A (0.40) | NR1H2NR1H3RXRAPDE4APDE4C | |
| SCHEMBL4017722 | 0.73 | NR1H2 (0.74) | NR1H2NR1H3RXRAGLO1TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |