Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 7/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012080 | 0.91 | NR1H2 (0.47) | NR1H2NR1H3PDE4APDE4CPDE4D | |
| SCHEMBL4018578 | 0.85 | PTGDR2 (0.41) | NR1H2NR1H3PDE4APDE4CPDE4D | |
| SCHEMBL4016970 | 0.85 | NR1H3 (0.50) | NR1H2NR1H3PDE4APDE4CPDE4D | |
| SCHEMBL4013386 | 0.80 | PTGDR2 (0.39) | NR1H2NR1H3PDE4APDE4CPDE4D | |
| SCHEMBL4012347 | 0.80 | NR1H3 (0.45) | NR1H2NR1H3PDE4APDE4CPDE4D | |
| SCHEMBL4015476 | 0.76 | NR1H2 (0.53) | NR1H2NR1H3PDE4APDE4CPDE4D | |
| SCHEMBL4014835 | 0.72 | NR1H2 (0.39) | NR1H2NR1H3RXRACHRM1DRD2 | |
| SCHEMBL4012417 | 0.71 | NR1H2 (0.51) | NR1H2NR1H3PTGDR2RXRAMAPK14 | |
| SCHEMBL4010255 | 0.70 | NR1H2 (0.48) | NR1H2NR1H3PDE4APDE4CPDE4D | |
| SCHEMBL2910645 | 0.70 | SOS1 (0.51) | CHRM1DRD2DRD4DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |