Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1890409 | 0.85 | PPARG (0.46) | POLBAGTR1AGTR2PPARGMAPK14 | |
| SCHEMBL4015825 | 0.81 | PPARG (0.39) | AGTR1PPARG | |
| SCHEMBL1890240 | 0.80 | MAPK14 (0.42) | AGTR1AGTR2PPARGMAPK14 | |
| SCHEMBL1892153 | 0.75 | PPARG (0.46) | AGTR1AGTR2PPARGMAPK14 | |
| SCHEMBL4307218 | 0.74 | KDM4E (0.41) | POLBPPARGMAPK14LMNA | |
| SCHEMBL2842286 | 0.71 | AGTR1 (0.54) | AGTR1 | |
| SCHEMBL4011554 | 0.71 | PPARG (0.46) | POLBAGTR1AGTR2PPARGMAPK14 | |
| SCHEMBL4011289 | 0.70 | PPARG (0.47) | AGTR1PPARGMAPK14 | |
| SCHEMBL458899 | 0.69 | RARB (0.41) | MAPT | |
| SCHEMBL1886369 | 0.69 | PPARG (0.64) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074117-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008062905-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-29 | — | — | WO | disclosed |