Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019861 | 0.76 | KDM4E (0.64) | KDM4EHSD17B10KMT2A | |
| SCHEMBL4014392 | 0.57 | TNKS2 (0.44) | KDM4EHSD17B10KMT2A | |
| SCHEMBL16863715 | 0.57 | ALDH1A1 (0.41) | KDM4EHSD17B10 | |
| SCHEMBL13165457 | 0.56 | RXFP1 (0.49) | KMT2AL3MBTL1 | |
| SCHEMBL2075661 | 0.55 | KDM4E (0.43) | KDM4EHSD17B10KMT2AL3MBTL1 | |
| SCHEMBL11746774 | 0.54 | ALDH1A1 (0.62) | KDM4EHSD17B10KMT2AL3MBTL1 | |
| SCHEMBL13184255 | 0.54 | MAPT (0.37) | KDM4EHSD17B10KMT2AL3MBTL1 | |
| SCHEMBL211358 | 0.54 | RXFP1 (0.50) | KMT2AL3MBTL1 | |
| Bromide SCHEMBL6121613 | 0.53 | SMN1; SMN2 (0.49) | KMT2AL3MBTL1 | |
| SCHEMBL10672138 | 0.53 | ALDH1A1 (0.49) | KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |