Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 14/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 14/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 13/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 12/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.41 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.41 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019004 | 0.69 | TNKS2 (0.42) | TNKS2PARP2PARP15PARP10PARP14 | |
| SCHEMBL4019007 | 0.69 | TNKS2 (0.46) | TNKS2PARP2PARP15PARP10PARP14 | |
| SCHEMBL4017830 | 0.67 | KDM4E (0.44) | KDM4EHSD17B10KMT2A | |
| SCHEMBL3456826 | 0.64 | KDM4E (0.49) | KDM4EHSD17B10GRM5KMT2A | |
| SCHEMBL4019861 | 0.60 | KDM4E (0.64) | KDM4EHSD17B10KMT2A | |
| SCHEMBL4019082 | 0.60 | KDM4E (0.64) | KDM4EHSD17B10GRM5KMT2A | |
| SCHEMBL673415 | 0.59 | TNKS2 (1.00) | TNKS2PARP2PARP15PARP10PARP14 | |
| SCHEMBL2087904 | 0.56 | HSD17B10 (0.40) | KDM4EHSD17B10KMT2A | |
| SCHEMBL102004 | 0.54 | ALDH1A1 (0.40) | KDM4EKMT2A | |
| SCHEMBL6168889 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |
| WO-2009087218-A1 | THIAZOLTRIAZOLES AND THIAZOLIMIDAZOLES AS ANTAGONISTS OF THE MGLUR5 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |
| WO-2009087218-A1 | THIAZOLTRIAZOLES AND THIAZOLIMIDAZOLES AS ANTAGONISTS OF THE MGLUR5 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |