Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SLC11A2 | P49281 | 2/20 | 0.47 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.46 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.46 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.46 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.46 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.46 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.46 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.46 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4168870 | 0.99 | HTT (0.49) | HTTHPGDSLC11A2ATP1A1ATP1B1 | |
| Bromide SCHEMBL4023459 | 0.89 | ATP1A1 (0.47) | HPGDSLC11A2ATP1A1ATP1B1ATP1A3 | |
| SCHEMBL4165386 | 0.88 | IDO1 (0.46) | HPGDSLC11A2ATP1A1ATP1B1ATP1A3 | |
| Bromide SCHEMBL4166299 | 0.87 | HTT (0.61) | HTTHPGDSLC11A2ATP1A1ATP1B1 | |
| SCHEMBL4019275 | 0.85 | HTT (0.63) | HTTHPGDSLC11A2SMN1; SMN2CYP3A4 | |
| Bromide SCHEMBL4018393 | 0.76 | HTT (0.49) | HTTHPGDSLC11A2ATP1A1ATP1B1 | |
| SCHEMBL3685690 | 0.74 | HTT (0.50) | HTTHPGDSLC11A2SMN1; SMN2CYP3A4 | |
| Hydrochloric Acid SCHEMBL28519909 | 0.71 | IDO1 (0.55) | HTTHPGDSLC11A2ATP1A1ATP1B1 | |
| Bromide SCHEMBL4023680 | 0.70 | SLC11A2 (0.53) | HPGDSLC11A2ATP1A1ATP1B1ATP1A3 | |
| SCHEMBL4177711 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061755-A1 | TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2009-05-27 | — | — | EP | disclosed |
| US-20090069408-A1 | TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-12 | — | — | US | disclosed |
| WO-2008109840-A1 | TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069408-A1 | TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | TFRC, SLC40A1, FECH | HTT 583/4885HPGD 1088/4885SLC11A2 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.