Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011991 | 0.84 | MEN1 (0.64) | MEN1KMT2AAKR1C3OPRK1PKM | |
| SCHEMBL4011625 | 0.84 | MEN1 (0.64) | MEN1KMT2AAKR1C3OPRK1PKM | |
| SCHEMBL3941072 | 0.81 | MEN1 (0.60) | MEN1KMT2AAKR1C3OPRK1PKM | |
| SCHEMBL4013512 | 0.78 | KMT2A (0.55) | MEN1KMT2AAKR1C3OPRK1PKM | |
| SCHEMBL10282809 | 0.78 | KMT2A (0.68) | MEN1KMT2AAKR1C3PKMESR2 | |
| SCHEMBL723811 | 0.78 | MEN1 (0.68) | MEN1KMT2AAKR1C3PKMESR2 | |
| SCHEMBL3088744 | 0.75 | PKM (0.44) | MEN1KMT2AAKR1C3OPRK1PKM | |
| SCHEMBL4012085 | 0.75 | AKR1C3 (0.73) | MEN1KMT2AAKR1C3 | |
| SCHEMBL14287576 | 0.70 | HRH3 (0.81) | MEN1KMT2AHRH3 | |
| SCHEMBL25073106 | 0.69 | MEN1 (0.59) | MEN1KMT2AAKR1C3PKMESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |