Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941072 | 0.87 | MEN1 (0.60) | KMT2AMEN1AKR1C3OPRK1PKM | |
| SCHEMBL4011991 | 0.83 | MEN1 (0.64) | KMT2AMEN1AKR1C3OPRK1PKM | |
| SCHEMBL4011625 | 0.81 | MEN1 (0.64) | KMT2AMEN1AKR1C3OPRK1PKM | |
| SCHEMBL4012429 | 0.78 | MEN1 (0.54) | KMT2AMEN1AKR1C3RAB9APKM | |
| SCHEMBL4016490 | 0.78 | MEN1 (0.60) | KMT2AMEN1AKR1C3OPRK1PKM | |
| SCHEMBL4012085 | 0.76 | AKR1C3 (0.73) | KMT2AMEN1AKR1C3 | |
| SCHEMBL20424528 | 0.75 | CYP2D6 (0.48) | KMT2ARAB9AOPRK1MAPTTSHR | |
| SCHEMBL14366673 | 0.75 | PKM (0.44) | KMT2AMEN1RAB9APKMMAPT | |
| SCHEMBL4017920 | 0.75 | PKM (0.44) | KMT2APKMMAPTTSHRALDH1A1 | |
| SCHEMBL30278456 | 0.74 | PKM (0.61) | KMT2AMEN1AKR1C3PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | claimed |
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |