SCHEMBL4016632

SCHEMBL4016632

CCCCc1nc(C)n(-c2cccc(CCO)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
APLNR P35414 1/20 0.40
ACHE P22303 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12993829 0.94 ACHE (0.41) APLNRACHE
SCHEMBL1895774 0.91 APLNR (0.42) APLNRACHE
SCHEMBL1893191 0.91 ACHE (0.42) APLNRACHE
SCHEMBL1894301 0.90 ACHE (0.43) ACHE
SCHEMBL2871115 0.90 ACHE (0.45) ACHE
SCHEMBL12357118 0.90 APLNR (0.41) APLNRACHE
SCHEMBL1893981 0.89 AGTR1 (0.43) APLNRACHE
SCHEMBL1895939 0.89 ACHE (0.41) APLNRACHE
SCHEMBL14136162 0.89 ACHE (0.41) APLNRACHE
SCHEMBL1892845 0.89 APLNR (0.40) APLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2074117-A2 HETEROMONOCYCLIC COMPOUND AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2009-07-01 EP disclosed
WO-2008062905-A2 HETEROMONOCYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-05-29 WO disclosed