Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019549 | 0.89 | PTGDR2 (0.42) | GPR119DGAT2PDK4NR1H2ESR2 | |
| SCHEMBL4012261 | 0.86 | SLC7A5 (0.43) | DGAT2SLC7A5SYK | |
| SCHEMBL15709719 | 0.83 | PDK4 (0.53) | PDK4NAMPT | |
| SCHEMBL21361618 | 0.81 | MGAT2 (0.44) | DGAT2PDK4NR1H2ESR2STS | |
| SCHEMBL30952437 | 0.81 | MGAT2 (0.44) | DGAT2PDK4NR1H2ESR2STS | |
| SCHEMBL22945388 | 0.81 | USP30 (0.48) | GPR119PDK4NR1H2ESR2MAPK1 | |
| SCHEMBL31334489 | 0.80 | USP30 (0.45) | GPR119DGAT2PDK4NR1H2ESR2 | |
| SCHEMBL6352947 | 0.79 | MAPK1 (0.49) | GPR119PDK4NR1H2ESR2NAMPT | |
| SCHEMBL31173305 | 0.79 | PDK4 (0.45) | GPR119DGAT2PDK4NR1H2ESR2 | |
| SCHEMBL25378040 | 0.79 | PDK4 (0.48) | PDK4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |