Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016687 | 0.89 | GPR119 (0.40) | PDK4GPR119DGAT2ESR2NR1H2 | |
| SCHEMBL22945388 | 0.85 | USP30 (0.48) | PDK4GPR119ESR2NR1H2NR1H3 | |
| SCHEMBL6352947 | 0.84 | MAPK1 (0.49) | PDK4GPR119ESR2NR1H2MAPK1 | |
| SCHEMBL31334489 | 0.82 | USP30 (0.45) | PDK4GPR119DGAT2ESR2NR1H2 | |
| SCHEMBL21425203 | 0.81 | MAPK1 (0.41) | PDK4GPR119DGAT2ESR2NR1H2 | |
| SCHEMBL22944628 | 0.81 | NAMPT (0.48) | PDK4GPR119ESR2NR1H2MAPK1 | |
| SCHEMBL21361618 | 0.81 | MGAT2 (0.44) | PDK4DGAT2ESR2NR1H2STS | |
| SCHEMBL30952437 | 0.81 | MGAT2 (0.44) | PDK4DGAT2ESR2NR1H2STS | |
| SCHEMBL31420092 | 0.77 | CDK12 (0.45) | GPR119DGAT2ACHE | |
| SCHEMBL26986892 | 0.77 | CDK12 (0.45) | GPR119DGAT2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101490001-A | Substituted phenylacetic acids as DP-2 antagonists | ICOS CORP (US) | 2009-07-22 | — | — | CN | disclosed |
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |