Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.41 |
| ▸ | TNKS | O95271 | 5/20 | 0.41 |
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008624 | 0.90 | USP2 (0.41) | TSHRHSD17B10USP2MAPK1KDM4E | |
| SCHEMBL4010739 | 0.81 | SIRT2 (0.45) | TSHRHSD17B10USP2MAPK1TNKS2 | |
| SCHEMBL8042850 | 0.80 | ALDH1A1 (0.47) | TSHRHSD17B10USP2MAPK1KDM4E | |
| SCHEMBL4007745 | 0.78 | SIRT2 (0.48) | TSHRHSD17B10USP2MAPK1KDM4E | |
| SCHEMBL4007817 | 0.74 | SIRT2 (0.45) | TSHRHSD17B10USP2MAPK1ALDH1A1 | |
| SCHEMBL4011132 | 0.74 | DHPS (0.41) | MAPK1ALDH1A1GAARAB9AMAPT | |
| SCHEMBL4009335 | 0.72 | ALDH1A1 (0.38) | TSHRMAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL8036853 | 0.71 | SIRT2 (0.54) | TSHRHSD17B10USP2MAPK1ALDH1A1 | |
| SCHEMBL4014162 | 0.70 | TSHR (0.38) | TSHRMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8676878 | 0.65 | POLB (0.64) | TSHRHSD17B10USP2MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080242-A1 | SUBSTITUTED 4-AMINOPYRIMIDINE-5-CARBOXYLIC ACID AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-02 | — | — | WO | disclosed |