Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TNKS | O95271 | 4/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4010739 | 0.86 | SIRT2 (0.45) | SIRT2SIRT1SIRT3HSD17B10MAPK1 | |
| SCHEMBL4007817 | 0.86 | SIRT2 (0.45) | SIRT2SIRT1SIRT3HSD17B10MAPK1 | |
| SCHEMBL8026733 | 0.80 | SIRT2 (0.56) | SIRT2SIRT1SIRT3HSD17B10MAPK1 | |
| SCHEMBL4017101 | 0.78 | TSHR (0.43) | SIRT2SIRT1SIRT3HSD17B10MAPK1 | |
| SCHEMBL8345138 | 0.76 | SIRT2 (0.59) | SIRT2SIRT1SIRT3HSD17B10RAB9A | |
| SCHEMBL4008624 | 0.75 | USP2 (0.41) | SIRT2SIRT1SIRT3HSD17B10MAPK1 | |
| SCHEMBL8036853 | 0.73 | SIRT2 (0.54) | SIRT2SIRT1SIRT3HSD17B10MAPK1 | |
| SCHEMBL8022429 | 0.71 | SIRT2 (0.52) | SIRT2SIRT1SIRT3HSD17B10MAPK1 | |
| SCHEMBL8032162 | 0.71 | SIRT2 (0.52) | SIRT2SIRT1SIRT3HSD17B10MAPK1 | |
| SCHEMBL4011731 | 0.71 | MAPT (0.41) | SIRT2SIRT1SIRT3TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080242-A1 | SUBSTITUTED 4-AMINOPYRIMIDINE-5-CARBOXYLIC ACID AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-02 | — | — | WO | disclosed |