SCHEMBL4017159

SCHEMBL4017159

CNCCCS(=O)(=O)c1cccc(Br)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.46
ATM Q13315 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.41
HSD17B2 P37059 1/20 0.39
EDNRB P24530 2/20 0.38
EDNRA P25101 2/20 0.38
CARM1 Q86X55 1/20 0.37
PRMT6 Q96LA8 1/20 0.37
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
PGR P06401 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4013557 0.85 ATM (0.43) ATML3MBTL1HSD17B2EDNRBEDNRA
SCHEMBL17364184 0.85 ATM (0.45) ATML3MBTL1HSD17B2HDAC3HDAC4
SCHEMBL1710715 0.82 ATM (0.41) ATML3MBTL1HSD17B2EDNRBEDNRA
SCHEMBL2555899 0.80 ATM (0.42) ATML3MBTL1HSD17B2EDNRBEDNRA
SCHEMBL7302021 0.80 PSIP1 (0.52) L3MBTL1HDAC3HDAC4HDAC1HDAC7
SCHEMBL1369364 0.79 CA2 (0.50) ATML3MBTL1HSD17B2HDAC3HDAC4
SCHEMBL8559958 0.79 ATM (0.43) ATML3MBTL1HDAC3HDAC4HDAC1
SCHEMBL263686 0.78 ATM (0.46) ATML3MBTL1HSD17B2EDNRBEDNRA
SCHEMBL2552754 0.78 ALDH1A1 (0.48) TAAR1ATMHTR6
SCHEMBL2443608 0.78 CA2 (0.51) ATML3MBTL1HSD17B2HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2074098-A2 QUINOLINE COMPOUNDS Wyeth (US) 2009-07-01 EP disclosed
WO-2008049047-A2 QUINOLINE COMPOUNDS WYETH (US) 2008-04-24 WO disclosed