Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3482812 | 0.91 | ALDH1A1 (0.45) | ALDH1A1TSHRLMNACHRNB2CHRNB4 | |
| SCHEMBL28207526 | 0.83 | CHRM2 (0.52) | ALDH1A1TSHRLMNACHRNB2CHRNB4 | |
| SCHEMBL9278775 | 0.81 | ALDH1A1 (0.64) | ALDH1A1TSHRLMNAPOLBHSD17B10 | |
| SCHEMBL13434152 | 0.80 | ALDH1A1 (0.58) | ALDH1A1TSHRLMNACHRNB2CHRNB4 | |
| SCHEMBL27364470 | 0.79 | CCR6 (0.55) | ALDH1A1TSHRLMNAL3MBTL1KMT2A | |
| SCHEMBL2182156 | 0.77 | LMNA (0.49) | ALDH1A1TSHRLMNAPOLBHSD17B10 | |
| SCHEMBL2182432 | 0.77 | LMNA (0.49) | ALDH1A1TSHRLMNAPOLBHSD17B10 | |
| SCHEMBL13434141 | 0.77 | ALDH1A1 (0.56) | ALDH1A1TSHRLMNACHRNB2CHRNB4 | |
| SCHEMBL4018145 | 0.77 | LMNA (0.56) | ALDH1A1TSHRLMNAL3MBTL1MEN1 | |
| SCHEMBL31126813 | 0.76 | ALDH1A1 (0.45) | ALDH1A1TSHRLMNAPOLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074107-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008057254-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-05-15 | — | — | WO | disclosed |