Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017663 | 1.00 | HSP90AB1 (0.39) | HSP90AB1HSP90AA1ALDH1A1HSD17B10MPO | |
| SCHEMBL1864503 | 0.83 | HSP90AB1 (0.52) | HSP90AB1HSP90AA1ALDH1A1HSD17B10MPO | |
| SCHEMBL4016961 | 0.81 | APOBEC3A (0.32) | — | |
| SCHEMBL14201605 | 0.81 | MPO (0.47) | HSP90AB1HSP90AA1ALDH1A1HSD17B10MPO | |
| SCHEMBL1669717 | 0.77 | HSP90AA1 (0.45) | HSP90AB1HSP90AA1ALDH1A1HSD17B10MPO | |
| SCHEMBL1670138 | 0.75 | TP53 (0.41) | ALDH1A1HSD17B10MPOSLC2A1ADORA1 | |
| SCHEMBL1860896 | 0.69 | HSP90AA1 (0.50) | HSP90AB1HSP90AA1ALDH1A1 | |
| SCHEMBL1670392 | 0.69 | PDE2A (0.37) | HSP90AB1HSP90AA1ALDH1A1HSD17B10MPO | |
| SCHEMBL1864346 | 0.67 | HSP90AA1 (0.50) | HSP90AB1HSP90AA1MEN1KMT2A | |
| SCHEMBL1856028 | 0.67 | HSP90AA1 (0.50) | HSP90AB1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074126-A2 | SULFAMOYL-CONTAINING DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049105-A2 | SULFAMOYL-CONTAINING DERIVATIVES AND USES THEREOF | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |