Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29589613 | 0.83 | ALDH1A1 (0.48) | ALDH1A1CASP1TSHRCYP3A4MAPT | |
| SCHEMBL27309614 | 0.83 | ALDH1A1 (0.48) | ALDH1A1CASP1TSHRCYP3A4MAPT | |
| SCHEMBL1887779 | 0.83 | MAPT (0.50) | ALDH1A1CASP1TSHRCYP3A4MAPT | |
| SCHEMBL29354986 | 0.81 | MAPT (0.44) | ALDH1A1CASP1TSHRCYP3A4MAPT | |
| SCHEMBL108757 | 0.81 | MAPT (0.44) | ALDH1A1CASP1TSHRCYP3A4MAPT | |
| SCHEMBL19899827 | 0.81 | MAPT (0.44) | ALDH1A1CASP1TSHRCYP3A4MAPT | |
| SCHEMBL791968 | 0.80 | ALDH1A1 (0.45) | ALDH1A1CASP1TSHRCYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL6256039 | 0.79 | MAPT (0.42) | ALDH1A1CASP1TSHRCYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL7132484 | 0.79 | MAPT (0.42) | ALDH1A1CASP1TSHRCYP3A4MAPT | |
| Bromide SCHEMBL26108834 | 0.79 | MAPT (0.42) | ALDH1A1CASP1TSHRCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2009-10-29 | — | — | US | disclosed |
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2009-10-29 | — | — | US | disclosed |
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2009-10-29 | — | — | US | disclosed |
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | disclosed |
| US-7285551-B2 | Fused-ring compounds and use thereof as drugs | JAPAN TOBACCO INC. (JP) | 2007-10-23 | — | — | US | disclosed |
| US-20070049593-A1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2007-03-01 | — | — | US | disclosed |
| US-4395577-A | OF AMIDOMETHYL NITROBENZENE WITH PHOSPHORUS OXYCHLORIDE | AMERICAN CYANAMID COMPANY (US) | 1983-07-26 | — | — | US | disclosed |
| US-4297127-A | PREEMERGENCE HERBICIDES | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| US-4261926-A | REACTION WITH KETONE IN PRESENCE OF PLATINUM HYDROGENATION CATALYST AND A PROMOTER ACID | AMERICAN CYANAMID COMPANY (US) | 1981-04-14 | — | — | US | disclosed |
| US-4251264-A | 4-CYANO SUBSTITUTED | AMERICAN CYANAMID COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
| US-4165231-A | 2,6-Dinitroaniline herbicides | AMERICAN CYANAMID COMPANY (US) | 1979-08-21 | — | — | US | disclosed |
| US-4101582-A | 2,6-Dinitroaniline herbicides | AMERICAN CYANAMID COMPANY (US) | 1978-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049593-A1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | POLI, TERT, ZC3HAV1 | ALDH1A1 750/4885CASP1 3158/4885TSHR 4089/4885 |
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | MAP3K1, MAP3K15, MAP3K5 | ALDH1A1 4322/4885CASP1 508/4885TSHR 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.