Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 10/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014828 | 0.79 | NR1H2 (0.72) | NR1H2NR1H3RXRA | |
| SCHEMBL4010841 | 0.78 | RORC (0.40) | NR1H2NR1H3RXRARORC | |
| SCHEMBL28046875 | 0.78 | NR4A2 (0.59) | NR4A2ADORA1DHODHPARP1CRHR1 | |
| SCHEMBL4012891 | 0.78 | NR1H2 (0.58) | NR1H2NR1H3RXRA | |
| SCHEMBL4017985 | 0.77 | NR1H3 (0.57) | NR1H2NR1H3NR4A2RXRA | |
| SCHEMBL4013872 | 0.77 | NR1H2 (0.59) | NR1H2NR1H3RXRA | |
| SCHEMBL4011035 | 0.75 | NR1H2 (0.50) | NR1H2NR1H3RXRA | |
| SCHEMBL4013817 | 0.73 | NR4A2 (0.54) | NR4A2DHODHPARP1CRHR1 | |
| SCHEMBL4014835 | 0.72 | NR1H2 (0.39) | NR1H2NR1H3RXRARORC | |
| SCHEMBL4684800 | 0.72 | PTPN1 (0.47) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |