Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MGLL | Q99685 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29082769 | 0.89 | CYP1A2 (0.80) | CYP1A2CYP2D6FAAHALDH1A1POLB | |
| SCHEMBL1507165 | 0.88 | CYP1A2 (0.78) | CYP1A2CYP2D6FAAHMGLL | |
| SCHEMBL640619 | 0.87 | CYP1A2 (0.76) | CYP1A2CYP2D6FAAHALDH1A1POLB | |
| SCHEMBL18424173 | 0.85 | CYP1A2 (0.73) | CYP1A2CYP2D6FAAHALDH1A1POLB | |
| SCHEMBL25075298 | 0.83 | CYP1A2 (0.71) | CYP1A2CYP2D6FAAHALDH1A1POLB | |
| SCHEMBL2103545 | 0.83 | CYP1A2 (0.70) | CYP1A2CYP2D6FAAHMGLL | |
| SCHEMBL5653105 | 0.83 | POLB (0.71) | CYP1A2CYP2D6FAAHALDH1A1POLB | |
| SCHEMBL26042174 | 0.82 | CYP1A2 (0.69) | CYP1A2CYP2D6FAAHALDH1A1POLB | |
| SCHEMBL10459207 | 0.82 | CYP1A2 (0.69) | CYP1A2CYP2D6ALDH1A1MGLL | |
| SCHEMBL13645932 | 0.82 | CYP1A2 (0.69) | CYP1A2CYP2D6ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655640-B2 | Camptothecin analogs and methods of preparation thereof | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-02-02 | — | — | US | disclosed |
| US-7514418-B2 | Camptothecin analogs and methods of preparation thereof | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514418-B2 | Camptothecin analogs and methods of preparation thereof | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070259905-A1 | Camptothecin analogs and methods of preparation thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-11-08 | — | — | US | disclosed |
| US-6150343-A | 10-HYDROXY-7-SUBSTITUTED SILYLCAMPTOTHECIN DERIVATIVE IS USED AS ANTICARCINOGENIC AND ANTITUMOR AGENT | UNIVERSITY OF PITTSBURGH (US) | 2000-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259905-A1 | Camptothecin analogs and methods of preparation thereof | ADCY9, BCL9, ADCY10 | CYP1A2 703/4885CYP2D6 619/4885FAAH 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.