Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3623386 | 0.92 | HTR6 (0.51) | HTR6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4018461 | 0.89 | HTR6 (0.49) | HTR6HDAC3HDAC4HDAC1HDAC7 | |
| Trifluoroacetic Acid SCHEMBL4021249 | 0.84 | HTR6 (0.61) | HTR6 | |
| Trifluoroacetic Acid SCHEMBL4018381 | 0.82 | HTR6 (0.48) | HTR6LMNARORC | |
| SCHEMBL3613851 | 0.82 | HTR6 (0.48) | HTR6HDAC3HDAC4HDAC1HDAC7 | |
| Trifluoroacetic Acid SCHEMBL3625968 | 0.80 | HTR6 (0.53) | HTR6HDAC1HDAC2HDAC6RORC | |
| SCHEMBL743239 | 0.77 | HTR6 (0.64) | HTR6HDAC3HDAC4HDAC1HDAC7 | |
| Trifluoroacetic Acid SCHEMBL6174815 | 0.77 | HTR6 (0.65) | HTR6BCHE | |
| Trifluoroacetic Acid SCHEMBL3620059 | 0.77 | HTR6 (0.56) | HTR6 | |
| Trifluoroacetic Acid SCHEMBL3619111 | 0.76 | HTR6 (0.48) | HTR6RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046741-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (publ) (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003703-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2008-01-10 | — | — | WO | disclosed |