Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4018688 | 1.00 | HSD17B10 (0.48) | HSD17B10CREBBPALDH1A1POLBBLM | |
| SCHEMBL13960699 | 1.00 | HSD17B10 (0.48) | HSD17B10CREBBPALDH1A1POLBBLM | |
| SCHEMBL3123562 | 0.81 | GAA (0.51) | HSD17B10CREBBPALDH1A1POLBBLM | |
| SCHEMBL13960685 | 0.81 | PBRM1 (0.38) | HSD17B10POLBBLMITGB3ITGB2 | |
| SCHEMBL13961367 | 0.80 | HSD17B10 (0.35) | HSD17B10 | |
| SCHEMBL13960703 | 0.80 | ALDH1A1 (0.39) | HSD17B10CREBBPALDH1A1POLBBLM | |
| SCHEMBL13960203 | 0.80 | ACHE (0.35) | HSD17B10ALDH1A1POLBBLMITGB3 | |
| SCHEMBL13960207 | 0.80 | ALDH1A1 (0.39) | HSD17B10CREBBPALDH1A1POLBBLM | |
| SCHEMBL13960694 | 0.80 | SIRT1 (0.40) | HSD17B10GAAIDO1 | |
| SCHEMBL13960704 | 0.79 | ALDH1A1 (0.39) | HSD17B10CREBBPALDH1A1POLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015179-A1 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009015179-A1 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |