Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021018 | 0.82 | OPRK1 (0.40) | OPRK1OPRM1OPRD1KCNH2HRH3 | |
| SCHEMBL4017396 | 0.82 | HCRTR1 (0.41) | HCRTR1HCRTR2OPRK1OPRM1OPRD1 | |
| SCHEMBL5722464 | 0.82 | HCRTR1 (0.41) | HCRTR1HCRTR2OPRK1OPRM1OPRD1 | |
| SCHEMBL4021779 | 0.81 | KDM4E (0.42) | HCRTR1HCRTR2OPRK1OPRM1OPRD1 | |
| SCHEMBL4023573 | 0.77 | OPRK1 (0.44) | OPRK1OPRM1OPRD1KCNH2HRH3 | |
| SCHEMBL4024054 | 0.75 | OPRM1 (0.44) | OPRK1OPRM1OPRD1KCNH2HRH3 | |
| SCHEMBL4019170 | 0.75 | OPRK1 (0.42) | OPRK1OPRM1OPRD1KCNH2HRH3 | |
| SCHEMBL5397291 | 0.74 | OPRM1 (0.40) | OPRK1OPRM1OPRD1HTR6KCNH2 | |
| SCHEMBL4026825 | 0.74 | OPRM1 (0.43) | OPRK1OPRM1OPRD1HRH3 | |
| SCHEMBL4019776 | 0.73 | OPRM1 (0.46) | OPRK1OPRM1OPRD1KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40838-E1 | 2-azabicyclo[3.3.1]nonane derivatives | PFIZER INC. (US) | 2009-07-07 | — | — | US | claimed |
| US-7056930-B2 | for treatment of disease states, disorders and conditions mediated by opioid receptors; for example, irritable bowel syndrome, drug addiction, including alcohol addiction, depression, anxiety, schizophrenia, eating disorders | PFIZER INC. (US) | 2006-06-06 | — | — | US | claimed |
| US-20040204445-A1 | 2-Azabicyclo[3.3.1]nonane derivatives | PFIZER INC. | 2004-10-14 | — | — | US | claimed |
| US-RE40838-E1 | 2-azabicyclo[3.3.1]nonane derivatives | PFIZER INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7056930-B2 | for treatment of disease states, disorders and conditions mediated by opioid receptors; for example, irritable bowel syndrome, drug addiction, including alcohol addiction, depression, anxiety, schizophrenia, eating disorders | PFIZER INC. (US) | 2006-06-06 | — | — | US | disclosed |
| US-20040204445-A1 | 2-Azabicyclo[3.3.1]nonane derivatives | PFIZER INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204445-A1 | 2-Azabicyclo[3.3.1]nonane derivatives | OPRD1, OPRK1, OPRM1 | HCRTR1 41/4885HCRTR2 49/4885OPRK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.