Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.75 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 5/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.73 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019371 | 0.89 | ALDH1A1 (0.84) | HRH3MAPK1HRH4TSHRNPSR1 | |
| SCHEMBL4024863 | 0.88 | HRH3 (1.00) | HRH3MAPK1HRH4TSHRNPSR1 | |
| SCHEMBL29761993 | 0.87 | SLC1A2 (0.77) | HRH3MAPK1HRH4TSHRNPSR1 | |
| SCHEMBL29761985 | 0.84 | SLC1A3 (1.00) | HRH3MAPK1HRH4TSHRNPSR1 | |
| SCHEMBL29761952 | 0.84 | NPSR1 (0.90) | HRH3TSHRNPSR1MEN1KMT2A | |
| SCHEMBL18326830 | 0.82 | TSHR (0.68) | HRH3MAPK1HRH4TSHRNPSR1 | |
| SCHEMBL29761962 | 0.81 | SLC1A3 (1.00) | HRH3MAPK1HRH4TSHRNPSR1 | |
| SCHEMBL4188505 | 0.80 | HRH3 (0.84) | HRH3MAPK1HRH4TSHRNPSR1 | |
| SCHEMBL4182903 | 0.79 | HRH3 (0.80) | HRH3TSHRNPSR1MEN1KMT2A | |
| SCHEMBL18326831 | 0.79 | TSHR (0.64) | HRH3MAPK1HRH4TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | claimed |
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |