Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.72 |
| ▸ | TSHR | P16473 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019371 | 0.91 | ALDH1A1 (0.84) | HRH3ALDH1A1SMN1; SMN2MAPTTDP1 | |
| SCHEMBL4186008 | 0.90 | HRH3 (0.84) | HRH3ALDH1A1SMN1; SMN2MAPTTDP1 | |
| SCHEMBL4194198 | 0.89 | HRH3 (1.00) | HRH3ALDH1A1SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL4182572 | 0.84 | HRH3 (0.84) | HRH3ALDH1A1SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL4020529 | 0.79 | HRH3 (0.79) | HRH3ALDH1A1SMN1; SMN2NPSR1TSHR | |
| SCHEMBL4024863 | 0.77 | HRH3 (1.00) | HRH3ALDH1A1NPSR1TSHRLMNA | |
| SCHEMBL4185921 | 0.75 | HRH3 (0.86) | HRH3ALDH1A1NPSR1TSHR | |
| SCHEMBL29761952 | 0.73 | NPSR1 (0.90) | HRH3ALDH1A1NPSR1TSHRLMNA | |
| SCHEMBL4188505 | 0.73 | HRH3 (0.84) | HRH3ALDH1A1NPSR1TSHRLMNA | |
| SCHEMBL18326831 | 0.72 | TSHR (0.64) | HRH3ALDH1A1SMN1; SMN2MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | claimed |
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |