SCHEMBL4020642

SCHEMBL4020642

C=C(C(=O)O)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.59
CES1 P23141 2/20 0.59
SRD5A2 P31213 2/20 0.57
PTPN1 P18031 2/20 0.55
GSK3B P49841 2/20 0.50
NR4A1 P22736 1/20 0.50
NR4A2 P43354 1/20 0.50
NR4A3 Q92570 1/20 0.50
CYP1A1 P04798 1/20 0.46
MAOB P27338 1/20 0.46
CYP1B1 Q16678 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
EPHX2 P34913 2/20 0.45
MEN1 O00255 1/20 0.44
HPGD P15428 1/20 0.44
TSHR P16473 1/20 0.44
KMT2A Q03164 1/20 0.44
HSD11B1 P28845 1/20 0.44
CYP2C8 P10632 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27901792 0.98 CES2 (0.57) CES2CES1SRD5A2PTPN1GSK3B
SCHEMBL29869060 0.94 CES2 (0.53) CES2CES1SRD5A2PTPN1GSK3B
SCHEMBL713716 0.82 TSHR (0.47) CES2CES1SRD5A2HPGDTSHR
SCHEMBL1124738 0.82 CES2 (0.57) CES2CES1SRD5A2PTPN1GSK3B
SCHEMBL28587857 0.82 CES2 (0.57) CES2CES1SRD5A2PTPN1GSK3B
SCHEMBL30547886 0.79 CES2 (0.59) CES2SRD5A2MAOB
SCHEMBL4578492 0.79 SRD5A2 (0.57) SRD5A2NR4A2NPC1RAB9AEPHX2
SCHEMBL3058646 0.78 CES2 (0.78) CES2CES1SRD5A2PTPN1GSK3B
Ethylene SCHEMBL715322 0.78 SRD5A2 (0.80) CES2CES1SRD5A2PTPN1GSK3B
SCHEMBL78879 0.78 SRD5A2 (0.87) CES2CES1SRD5A2PTPN1GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116789517-A Aryl or heteroaryl derivative and organic electroluminescent element comprising same 株式会社乐普拓 2023-09-22 CN disclosed
CN-116710432-A Organic compound and organic electroluminescent device comprising the same 株式会社乐普拓 2023-09-05 CN disclosed
CN-116568683-A Dibenzofive-membered ring compound and organic electroluminescent device comprising same 株式会社乐普拓 2023-08-08 CN disclosed
CN-109796561-B Aromatic ring polycarboxylic acid water reducing agent mother liquor and preparation method and application thereof 科之杰新材料集团(贵州)有限公司 2021-06-15 CN disclosed
CN-109369637-B Novel kojic acid derivative containing 1,3, 4-thiadiazole and application thereof 湖南科技大学 2021-04-06 CN disclosed
CN-105566021-B A kind of α, the preparation method of beta-unsaturated carboxylic acid class compound 中国科学技术大学 2018-05-29 CN disclosed
WO-2009095726-A1 ACRYLAMIDE DERIVATIVES AS VANILLOID RECEPTOR 1 MODULATORS GLENMARK PHARMACEUTICALS, S.A. (US) 2009-08-06 WO disclosed