Cyproheptadine

Cyproheptadine

SCHEMBL4021

CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1

The experimentally established mechanism targets of Cyproheptadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 known ✓ P35367 4/20 1.00
SETD7 Q8WTS6 7/20 1.00
CHRM2 P08172 5/20 1.00
CHRM1 P11229 5/20 1.00
ADRA1A P35348 5/20 1.00
KCNH2 Q12809 5/20 1.00
HTR1A P08908 4/20 1.00
ADRA2A P08913 4/20 1.00
DRD1 P21728 4/20 1.00
DRD3 P35462 4/20 1.00
HTR2A P28223 4/20 1.00
HTR2C P28335 4/20 1.00
HTR2B P41595 4/20 1.00
SLC6A2 P23975 3/20 1.00
SLC6A4 P31645 3/20 1.00
SLC6A3 Q01959 3/20 1.00
CYP2D6 P10635 3/20 1.00
CYP2C19 P33261 3/20 1.00
DRD2 P14416 3/20 1.00
ADRA2B P18089 3/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cyproheptadine SCHEMBL29369949 1.00 SETD7 (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
Cyproheptadine SCHEMBL7923153 1.00 SETD7 (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
Cyproheptadine SCHEMBL29380652 0.98 LMNA (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
Cyproheptadine SCHEMBL30772122 0.98 LMNA (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
Cyproheptadine SCHEMBL20610743 0.98 LMNA (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
Cyproheptadine SCHEMBL5500354 0.98 LMNA (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
Cyproheptadine SCHEMBL11779784 0.98 SETD7 (0.96) SETD7CHRM2CHRM1ADRA1AKCNH2
Cyproheptadine SCHEMBL41842 0.98 LMNA (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
Cyproheptadine SCHEMBL9934753 0.96 LMNA (0.97) SETD7CHRM2CHRM1ADRA1AKCNH2
Cyproheptadine SCHEMBL3005524 0.96 SETD7 (0.93) SETD7CHRM2CHRM1ADRA1AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 19009 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
US-20260115192-A1 PHARMACEUTICAL COMPOSITIONS SHENZHEN PHARMACIN CO LTD (CN) 2026-04-30 US claimed
US-12605402-B2 Therapeutic uses of oxidizing hypotonic acid solutions APR APPLIED PHARMA RESEARCH SA (CH) 2026-04-21 US claimed
EP-4725483-A1 COMBINATION COMPRISING AT LEAST ONE 5-HT2A RECEPTOR ANTAGONIST AND AT LEAST ONE 5-HT3 RECEPTOR ANTAGONIST AND ITS MEDICAL USE Université de Bordeaux (FR) 2026-04-15 EP claimed
EP-4704971-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2026-03-11 EP claimed
US-12569451-B2 Bio-inspired tissue-adhesive hydrogel patch and uses thereof Cellartgen Inc. (KR) 2026-03-10 US claimed
WO-2026042047-A1 COMPOSITIONS AND ARTICLES COMPRISING REVERSIBLE COMPLEXES OF CROSSLINKED CARRAGEENAN JOHNSON & JOHNSON VISION CARE, INC. (US) 2026-02-26 WO claimed
US-12550885-B2 Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells UNIVERSITY OF CINCINNATI (US) 2026-02-17 US claimed
EP-4691556-A2 HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF H. Lundbeck A/S (DK) 2026-02-11 EP claimed
EP-4691568-A2 LOW-DOSE BRIMONIDINE COMBINATIONS AND USES THEREOF Eye Therapies, LLC (US) 2026-02-11 EP claimed
EP-0036138-B1 COMPOSITION OF MATTER FOR TOPICAL APPLICATION COMPRISING A BIO-AFFECTING AGENT AND N,N-DIETHYL-M-TOLUAMIDE MERCK & CO. INC. (US) 1985-08-28 EP claimed
US-4524072-A Reduction of stroke damage ZIVIN JUSTIN A 1985-06-18 US claimed
US-4444778-A ANTISEROTONINE AGENTS COUGHLIN SHAUN R 1984-04-24 US claimed
US-4444780-A Method for treating atopic dermatitis ORTHO PHARMACEUTICAL CORPORATION (US) 1984-04-24 US claimed
EP-0104782-A2 A pharmaceutical composition for topical application for treating atopic dermatitis ORTHO PHARMACEUTICAL CORPORATION (US) 1984-04-04 EP claimed
US-4165376-A CYPROHEPTADINE LAKE SHORE ROENTGENOLOGY, LTD. (US) 1979-08-21 US claimed
US-4153700-A Treatment of the acute after-effects resulting from alcohol ingestion LAKE SHORE ROENTGENOLOGY LTD. (US) 1979-05-08 US claimed
US-4104382-A (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-08-01 US claimed
US-4000302-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-12-28 US claimed
US-3968115-A OR 11)-BROMO-10,11-DIHYDRO-5H-DIBENZO(A,D)-CYCLOHEPTEN-5-YLIDENE PIPERIDINE COMPOUNDSANTIHISTAMINE, APPETITE STIMULANT MERCK & CO., INC. (US) 1976-07-06 US claimed