Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyproheptadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.96 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | SETD7 | Q8WTS6 | 7/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.96 |
| ▸ | HTR1A | P08908 | 4/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.96 |
| ▸ | DRD1 | P21728 | 4/20 | 0.96 |
| ▸ | DRD3 | P35462 | 4/20 | 0.96 |
| ▸ | HTR2A | P28223 | 4/20 | 0.96 |
| ▸ | HTR2C | P28335 | 4/20 | 0.96 |
| ▸ | HTR2B | P41595 | 4/20 | 0.96 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.96 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyproheptadine SCHEMBL5500354 | 1.00 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL41842 | 1.00 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL30772122 | 1.00 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL20610743 | 1.00 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL27756503 | 0.98 | LMNA (0.97) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL9934753 | 0.98 | LMNA (0.97) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL7923153 | 0.98 | SETD7 (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL4021 | 0.98 | SETD7 (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL29369949 | 0.98 | SETD7 (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL11779784 | 0.96 | SETD7 (0.96) | LMNAMEN1MAPTPMP22KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025103411-A1 | CAS PROTEIN, CRISPR-CAS SYSTEM, AND USE THEREOF | 广州瑞风生物科技有限公司 | 2025-05-22 | — | — | WO | claimed |
| CN-115444712-B | Multi-degree-of-freedom hand function rehabilitation device | 中国科学院长春光学精密机械与物理研究所 | 2024-09-20 | — | — | CN | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| CN-115590981-A | Oral delivery system of bioactive macromolecular drug and preparation method thereof | 北京化工大学（CN） | 2023-01-13 | — | — | CN | claimed |
| CN-114949369-A | Artificial tissue organ packaging device and preparation method and application thereof | 清华大学 | 2022-08-30 | — | — | CN | claimed |
| WO-2022124342-A1 | AGENT FOR CANCER THERAPY, AND SCREENING METHOD FOR ACTIVE INGREDIENT THEREOF | 国立大学法人 岡山大学 | 2022-06-16 | — | — | WO | claimed |
| CN-110503061-B | Multi-feature-fused multi-factor video occlusion area detection method and system | 燕山大学 | 2022-02-11 | — | — | CN | claimed |
| CN-122055150-A | Cyproheptadine derivatives | 思凯生科股份有限公司 | 2026-05-15 | — | — | CN | disclosed |
| WO-2025245328-A1 | WIRELESS CHARGING CASE | VALVE CORPORATION (US) | 2025-11-27 | — | — | WO | disclosed |
| EP-3808339-B1 | PHARMACEUTICAL NANOPARTICLES SHOWING IMPROVED MUCOSAL TRANSPORT | ALCON INC (CH) | 2025-11-12 | — | — | EP | disclosed |
| EP-4612562-A1 | SECURE SOFTWARE COMMUNICATION WITH AUTONOMOUS VEHICLES | Zoox, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2025103411-A1 | CAS PROTEIN, CRISPR-CAS SYSTEM, AND USE THEREOF | 广州瑞风生物科技有限公司 | 2025-05-22 | — | — | WO | disclosed |
| EP-4487448-A1 | SOFTWARE-DEFINED ENERGY STORAGE SYSTEM INTERFACE | Reon Technology, Inc. (US) | 2025-01-08 | — | — | EP | disclosed |
| EP-4008355-A1 | PHARMACEUTICAL NANOPARTICLES SHOWING IMPROVED MUCOSAL TRANSPORT | Kala Pharmaceuticals, Inc. (US) | 2022-06-08 | — | — | EP | disclosed |
| US-20220154213-A1 | BOCAPARVOVIRUS SMALL NONCODING RNA AND USES THEREOF | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2022-05-19 | — | — | US | disclosed |
| CN-114466658-A | Orally delivered therapeutic compositions and uses thereof | 沈海发 | 2022-05-10 | — | — | CN | disclosed |
| US-11318088-B2 | Compositions and methods utilizing poly(vinyl alcohol) and/or other polymers that aid particle transport in mucus | KALA PHARMACEUTICALS, INC. (US) | 2022-05-03 | — | — | US | disclosed |
| WO-2022060350-A1 | FACILITATING IMPROVED USE OF STOCHASTIC ASSOCIATIVE MEMORY | INTEL CORPORATION (US) | 2022-03-24 | — | — | WO | disclosed |
| US-20220073500-A1 | CRYSTALLINE PHARMACEUTICAL AND METHODS OF PREPARATION AND USE THEREOF | NOVARTIS PHARMACEUTICALS CORPORATION (US) | 2022-03-10 | — | — | US | disclosed |
| CN-110503061-B | Multi-feature-fused multi-factor video occlusion area detection method and system | 燕山大学 | 2022-02-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11318088-B2 | Compositions and methods utilizing poly(vinyl alcohol) and/or other polymers that aid particle transport in mucus | MUC1, EPCAM, CD44 | HRH1 1167/4885LMNA 2726/4885MEN1 2627/4885 |
| US-20220073500-A1 | CRYSTALLINE PHARMACEUTICAL AND METHODS OF PREPARATION AND USE THEREOF | VCAM1, ICAM1, HLA-DRB1 | HRH1 526/4885LMNA 1100/4885MEN1 2506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.