Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyproheptadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.96 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | SETD7 | Q8WTS6 | 7/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.96 |
| ▸ | HTR1A | P08908 | 4/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.96 |
| ▸ | DRD1 | P21728 | 4/20 | 0.96 |
| ▸ | DRD3 | P35462 | 4/20 | 0.96 |
| ▸ | HTR2A | P28223 | 4/20 | 0.96 |
| ▸ | HTR2C | P28335 | 4/20 | 0.96 |
| ▸ | HTR2B | P41595 | 4/20 | 0.96 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.96 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyproheptadine SCHEMBL5500354 | 1.00 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL30772122 | 1.00 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL29380652 | 1.00 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL20610743 | 1.00 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL27756503 | 0.98 | LMNA (0.97) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL9934753 | 0.98 | LMNA (0.97) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL7923153 | 0.98 | SETD7 (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL4021 | 0.98 | SETD7 (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL29369949 | 0.98 | SETD7 (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL11779784 | 0.96 | SETD7 (0.96) | LMNAMEN1MAPTPMP22KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3664 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| CN-120081781-A | Cyproheptadine hydrochloride synthesis method | 海南长春花药业有限公司 | 2025-06-03 | — | — | CN | claimed |
| CN-118319853-A | Pharmaceutical composition containing cyproheptadine hydrochloride and preparation method thereof | 安徽杰玺医药有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-118021712-A | Preparation method of cyproheptadine hydrochloride transdermal ointment for increasing weight of cats | 华南农业大学 | 2024-05-14 | — | — | CN | claimed |
| CN-117402105-A | Preparation method of cyproheptadine hydrochloride | 云鹏医药集团有限公司 | 2024-01-16 | — | — | CN | claimed |
| CN-117388348-A | Method for detecting impurity elements in cyproheptadine hydrochloride | 核工业二0八大队 | 2024-01-12 | — | — | CN | claimed |
| EP-3500686-B1 | METHODS FOR DETECTING CRANIOPHARYNGIOMA AND FOR SELECTING MEDICAMENTS AND PATIENTS FOR TREATMENT | QUEST DIAGNOSTICS INVEST LLC (US) | 2024-01-10 | — | — | EP | claimed |
| CN-111562256-B | Electrochemiluminescence detection method for cyproheptadine hydrochloride | 西湖维泰(杭州)诊断技术有限公司 | 2023-12-26 | — | — | CN | claimed |
| CN-115252592-B | Application of antihistamine medicine in preparation of antibacterial medicine | 山东省妇幼保健院 | 2023-11-24 | — | — | CN | claimed |
| US-20230174641-A1 | ANTI-ACTH ANTIBODIES AND USE THEREOF | H LUNDBECK AS (DK) | 2023-06-08 | — | — | US | claimed |
| WO-1993007903-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| WO-1993007902-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| EP-0209403-B1 | PROCESS FOR PREPARING ULTRAFINE PARTICLES OF ORGANIC COMPOUNDS | Research Development Corporation of Japan (JP) | 1991-10-23 | — | — | EP | claimed |
| US-4913865-A | Process for preparing ultrafine particles of organic compounds | RESEARCH DEVELOPMENT CORP OF JAPAN (JP) | 1990-04-03 | — | — | US | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| EP-0036138-B2 | Composition of matter for topical application comprising a bio-affecting agent and N,N-diethyl-m-toluamide | MERCK & CO. INC. (US) | 1989-10-25 | — | — | EP | claimed |
| EP-0069385-B1 | USE OF EUCALYPTOL FOR ENHANCING SKIN PERMEATION OF BIOAFFECTING AGENTS | MERCK & CO. INC. (US) | 1987-10-14 | — | — | EP | claimed |
| EP-0209403-A2 | Process for preparing ultrafine particles of organic compounds | Research Development Corporation of Japan (JP) | 1987-01-21 | — | — | EP | claimed |
| EP-0036138-B1 | COMPOSITION OF MATTER FOR TOPICAL APPLICATION COMPRISING A BIO-AFFECTING AGENT AND N,N-DIETHYL-M-TOLUAMIDE | MERCK & CO. INC. (US) | 1985-08-28 | — | — | EP | claimed |
| EP-0036138-A2 | Composition of matter for topical application comprising a bio-affecting agent and N,N-diethyl-m-toluamide | MERCK & CO. INC. (US) | 1981-09-23 | — | — | EP | claimed |