SCHEMBL4021097

SCHEMBL4021097

CCOS(=O)(=O)c1ccccc1-c1cccs1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 1/20 0.44
ALDH1A1 P00352 3/20 0.43
GAA P10253 1/20 0.43
MAPT P10636 1/20 0.43
KEAP1 Q14145 1/20 0.43
LTA4H P09960 1/20 0.42
KDM4E B2RXH2 2/20 0.38
LMNA P02545 1/20 0.38
HPGD P15428 1/20 0.38
HTT P42858 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
TP53 P04637 1/20 0.37
POLB P06746 1/20 0.37
ERN1 O75460 1/20 0.37
ADORA2A P29274 1/20 0.37
ADORA1 P30542 1/20 0.37
DPP4 P27487 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
SCN9A Q15858 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27559786 0.83 ALDH1A1 (0.42) EDNRAALDH1A1GAAMAPTKEAP1
SCHEMBL15518348 0.82 EDNRA (0.46) EDNRAALDH1A1GAAMAPTLTA4H
SCHEMBL7198693 0.79 EDNRA (0.51) EDNRAALDH1A1MAPTLTA4HKDM4E
SCHEMBL778991 0.76 GAA (0.39) ALDH1A1GAALMNAHTTTP53
SCHEMBL29415266 0.76 GAA (0.39) ALDH1A1GAALMNAHTTTP53
SCHEMBL28357540 0.74 ALDH1A1 (0.42) ALDH1A1GAAMAPTKEAP1KDM4E
SCHEMBL28547668 0.74 EDNRA (0.47) EDNRAALDH1A1GAAMAPTLTA4H
SCHEMBL7950052 0.74 EDNRA (0.47) EDNRAALDH1A1GAAMAPTLTA4H
SCHEMBL3478457 0.74 SCN9A (0.49) EDNRASCN9A
SCHEMBL3794936 0.72 ALDH1A1 (0.48) ALDH1A1GAAMAPTLMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103119015-B Method for resolving nitrogen substituted (S) -5-alkoxy-2-aminotetralin derivatives UCB PHARMA GMBH (DE) 2016-01-27 CN claimed
CN-103119015-A Method for resolving nitrogen substituted -5-alkoxy-2-aminotetralin derivatives UCB PHARMA GMBH 2013-05-22 CN claimed
EP-2078025-A2 PROCESS FOR THE SYNTHESIS OF CLOPIDOGREL AND NEW FORMS OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KRKA, tovarna zdravil, d.d., Novo mesto (SI) 2009-07-15 EP claimed
WO-2008034912-A2 PROCESS FOR THE SYNTHESIS OF CLOPIDOGREL AND NEW FORMS OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) 2008-03-27 WO claimed
CN-1185225-C Improved process for preparing nitrogen-substituted aminotetralins ADERIS PHARMACEUTICAL CORP (US) 2005-01-19 CN claimed
CN-1391569-A Improved process for preparing nitrogen substituted amino 1,2,3, 4-tetralins ADERIS PHARMACEUTICAL CORP (US) 2003-01-15 CN claimed
CN-103119015-B Method for resolving nitrogen substituted (S) -5-alkoxy-2-aminotetralin derivatives UCB PHARMA GMBH (DE) 2016-01-27 CN disclosed
CN-103119015-A Method for resolving nitrogen substituted -5-alkoxy-2-aminotetralin derivatives UCB PHARMA GMBH 2013-05-22 CN disclosed
EP-2078025-A2 PROCESS FOR THE SYNTHESIS OF CLOPIDOGREL AND NEW FORMS OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KRKA, tovarna zdravil, d.d., Novo mesto (SI) 2009-07-15 EP disclosed
WO-2008034912-A2 PROCESS FOR THE SYNTHESIS OF CLOPIDOGREL AND NEW FORMS OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) 2008-03-27 WO disclosed
CN-1185225-C Improved process for preparing nitrogen-substituted aminotetralins ADERIS PHARMACEUTICAL CORP (US) 2005-01-19 CN disclosed
CN-1391569-A Improved process for preparing nitrogen substituted amino 1,2,3, 4-tetralins ADERIS PHARMACEUTICAL CORP (US) 2003-01-15 CN disclosed