SCHEMBL402137

SCHEMBL402137

[NH]Cc1ccc(N)cc1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4991113 0.83 NOS1 (0.32)
SCHEMBL400865 0.77 GFER (0.68)
SCHEMBL2642759 0.77 TAAR1 (0.56)
SCHEMBL2642245 0.75 HRH3 (0.58)
4,4'-Methylenedianiline SCHEMBL28001 0.73 CYP3A4 (1.00)
SCHEMBL3482770 0.73 CYP3A4 (1.00)
SCHEMBL6362775 0.73 CYP3A4 (1.00)
SCHEMBL8094139 0.73 CYP3A4 (1.00)
SCHEMBL3482833 0.73 GFER (1.00)
SCHEMBL1304762 0.73 CYP3A4 (1.00)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220211701-A1 TREATMENT OF CANCER UTILIZING AN IDENTIFIED ADENOSINE FINGERPRINT ARCUS BIOSCIENCES, INC. (US) 2022-07-07 US claimed
CN-114395005-A Modulators of extracellular 5' -nucleotidase and uses thereof 艾库斯生物科学有限公司 2022-04-26 CN claimed
CN-113874397-A Treatment of cancer using identified adenosine fingerprints 艾库斯生物科学有限公司 2021-12-31 CN claimed
CN-113795267-A Oncogene driven treatment of cancer 艾库斯生物科学有限公司 2021-12-14 CN claimed
EP-3761993-A1 PARENTERALLY ADMINISTERED IMMUNE ENHANCING DRUGS Arcus Biosciences, Inc. (US) 2021-01-13 EP claimed
US-20200405629-A1 PARENTERALLY ADMINISTERED IMMUNE ENHANCING DRUGS ARCUS BIOSCIENCES, INC. 2020-12-31 US claimed
CN-112004541-A Immunopotentiating medicine for parenteral administration 艾库斯生物科学有限公司 2020-11-27 CN claimed
US-20190309010-A1 MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF ARCUS BIOSCIENCES, INC. 2019-10-10 US claimed
WO-2019173682-A1 PARENTERALLY ADMINISTERED IMMUNE ENHANCING DRUGS ARCUS BIOSCIENCES, INC. (US) 2019-09-12 WO claimed
US-10239912-B2 Modulators of 5′-nucleotidase, ecto and the use thereof ARCUS BIOSCIENCES, INC. (US) 2019-03-26 US claimed
EP-3399984-A1 MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF Arcus Biosciences, Inc. (US) 2018-11-14 EP claimed
US-20170267710-A1 MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF ARCUS BIOSCIENCES, INC. 2017-09-21 US claimed
WO-2017120508-A1 MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF ARCUS BIOSCIENCES, INC. (US) 2017-07-13 WO claimed
EP-2142518-B1 3,4-DIHYDROQUINAZOLINE DERIVATIVES DONGWOO SYNTECH CO LTD (KR) 2012-05-02 EP claimed
US-8168646-B2 3,4-dihydroquinazoline derivatives DONGWOO SYNTECH CO., LTD. (KR) 2012-05-01 US claimed
WO-2010139288-A1 5,7-DISUBSTITUTED 3-ISOPROPYLPYRAZOLO[4,3-D]PYRIMIDINES FOR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS C3 BIO GMBH (DE) 2010-12-09 WO claimed
US-20100120803-A1 3,4-DIHYDROQUINAZOLINE DERIVATIVES DONGWOO SYNTECH CO., LTD. (KR) 2010-05-13 US claimed
EP-2142518-A1 3,4-DIHYDROQUINAZOLINE DERIVATIVES Dongwoo Syntech Co., Ltd. (KR) 2010-01-13 EP claimed
WO-2008136631-A1 3,4-DIHYDROQUINAZOLINE DERIVATIVES DONGWOO SYNTECH CO., LTD. (KR) 2008-11-13 WO claimed
US-20020058788-A1 Facile deprotection of Fmoc protected amino groups DISCOVERY PARTNERS INTERNATIONAL, INC. 2002-05-16 US claimed