Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.44 |
| ▸ | YAP1 | P46937 | 1/20 | 0.44 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11345894 | 0.94 | KDM4E (0.51) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL7009525 | 0.92 | HDAC3 (0.54) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL9671249 | 0.89 | SLC2A1 (0.47) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL20448668 | 0.86 | TEAD1 (0.47) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL9808024 | 0.86 | KDM4E (0.59) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL9808069 | 0.86 | KDM4E (0.55) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL9808062 | 0.81 | TEAD1 (0.53) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL7414719 | 0.80 | HDAC3 (0.54) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL10390452 | 0.80 | RAB9A (0.48) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL9672124 | 0.79 | SLC2A1 (0.44) | KDM4EALDH1A1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009098455-A1 | 2- (9H-XANTHEN-9-YL) -OXAZOL DERIVATIVES AS M3 MUSCARINIC RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE LUNG DISEASE | ASTRAZENECA AB (SE) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009098455-A1 | 2- (9H-XANTHEN-9-YL) -OXAZOL DERIVATIVES AS M3 MUSCARINIC RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE LUNG DISEASE | ASTRAZENECA AB (SE) | 2009-08-13 | — | — | WO | disclosed |
| WO-2008096128-A1 | OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES 2 | ARGENTA DISCOVERY LTD (GB) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008096128-A1 | OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES 2 | ARGENTA DISCOVERY LTD (GB) | 2008-08-14 | — | — | WO | disclosed |