Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4644169 | 0.95 | CA1 (0.44) | KDM5ACA1CA12CA9PHF8 | |
| SCHEMBL27883468 | 0.95 | KDM5A (0.46) | KDM5ACA1CA12CA9PHF8 | |
| Sulfuric Acid SCHEMBL2148402 | 0.87 | CA1 (0.46) | KDM5ACA1CA12CA9PHF8 | |
| Sulfuric Acid SCHEMBL5874269 | 0.87 | CA1 (0.46) | KDM5ACA1CA12CA9PHF8 | |
| Sulfuric Acid SCHEMBL27883459 | 0.87 | CA1 (0.46) | KDM5ACA1CA12CA9PHF8 | |
| SCHEMBL1131510 | 0.86 | KDM5A (0.41) | KDM5ACA1CA12CA9PHF8 | |
| SCHEMBL4004155 | 0.86 | KDM5A (0.49) | KDM5ACA1PHF8KDM4CCA2 | |
| SCHEMBL28730799 | 0.86 | KDM5A (0.49) | KDM5ACA1PHF8KDM4CCA2 | |
| SCHEMBL13359386 | 0.84 | CA12 (0.40) | KDM5ACA1CA12CA9PHF8 | |
| SCHEMBL29774219 | 0.84 | APP (0.41) | KDM5ACA1CA12CA9PHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553406-B2 | Process for removing polar impurities from hydrocarbons and mixtures of hydrocarbons | MERCK PATENT GMBH (DE) | 2009-06-30 | — | — | US | disclosed |
| US-20050010076-A1 | Process for removing polar impurities from hydrocarbons and mixtures of hydrocarbons | MERCK PATENT GMBH (DE) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050010076-A1 | Process for removing polar impurities from hydrocarbons and mixtures of hydrocarbons | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, AHR, HNRNPH3 | KDM5A 4170/4885CA1 4779/4885CA12 3855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.