Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 12/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13721566 | 1.00 | DRD4 (0.42) | DRD4CYP2C9CYP2C19DRD2CCR3 | |
| SCHEMBL4022167 | 1.00 | DRD4 (0.42) | DRD4CYP2C9CYP2C19DRD2CCR3 | |
| SCHEMBL4752775 | 0.95 | DRD2 (0.46) | DRD4DRD2CCR3 | |
| SCHEMBL4749499 | 0.94 | DRD2 (0.45) | DRD4DRD2CCR3 | |
| SCHEMBL4021763 | 0.89 | SMN1; SMN2 (0.37) | DRD4DRD2KDM2BMAPTTHRB | |
| SCHEMBL13720836 | 0.89 | SMN1; SMN2 (0.37) | DRD4DRD2KDM2BMAPTTHRB | |
| SCHEMBL4021768 | 0.89 | SMN1; SMN2 (0.37) | DRD4DRD2KDM2BMAPTTHRB | |
| SCHEMBL4019477 | 0.88 | DRD4 (0.41) | DRD4CYP2C9CYP2C19DRD2CCR3 | |
| SCHEMBL4024597 | 0.84 | KDM2B (0.45) | DRD2KDM2BSMN1; SMN2 | |
| SCHEMBL4021398 | 0.84 | KDM2B (0.45) | DRD2KDM2BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572814-B2 | 3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds | CYTOKINETICS, INCORPORATED (US) | 2009-08-11 | — | — | US | disclosed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |