Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13720836 | 1.00 | SMN1; SMN2 (0.37) | SMN1; SMN2THRBRXFP1KDM2BCHRM1 | |
| SCHEMBL4021768 | 1.00 | SMN1; SMN2 (0.37) | SMN1; SMN2THRBRXFP1KDM2BCHRM1 | |
| SCHEMBL4022167 | 0.89 | DRD4 (0.42) | SMN1; SMN2THRBRXFP1KDM2BDRD4 | |
| SCHEMBL13721566 | 0.89 | DRD4 (0.42) | SMN1; SMN2THRBRXFP1KDM2BDRD4 | |
| SCHEMBL4022160 | 0.89 | DRD4 (0.42) | SMN1; SMN2THRBRXFP1KDM2BDRD4 | |
| SCHEMBL4752775 | 0.87 | DRD2 (0.46) | DRD4DRD2 | |
| SCHEMBL4749499 | 0.87 | DRD2 (0.45) | DRD4DRD2 | |
| SCHEMBL13721648 | 0.85 | HSD11B1 (0.38) | SMN1; SMN2KDM2BKMT2AHTTMEN1 | |
| SCHEMBL5635169 | 0.82 | KMT2A (0.37) | SMN1; SMN2KDM2BKMT2AHTTMEN1 | |
| SCHEMBL5635174 | 0.82 | KMT2A (0.37) | SMN1; SMN2KDM2BKMT2AHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572814-B2 | 3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds | CYTOKINETICS, INCORPORATED (US) | 2009-08-11 | — | — | US | disclosed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |