Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028212 | 0.86 | TRPV1 (0.65) | TRPV1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4022954 | 0.85 | TRPV1 (1.00) | TRPV1ALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL283472 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDMAPTKDM4ELMNA | |
| SCHEMBL17776532 | 0.82 | TRPV1 (0.62) | TRPV1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4020193 | 0.81 | TRPV1 (0.67) | TRPV1ALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL3246360 | 0.81 | TRPV1 (0.63) | TRPV1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL30114438 | 0.81 | TRPV1 (0.64) | TRPV1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4023786 | 0.81 | TRPV1 (0.64) | TRPV1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL16269053 | 0.81 | TRPV1 (0.54) | TRPV1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL16269051 | 0.81 | TRPV1 (0.54) | TRPV1ALDH1A1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | claimed |
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | disclosed |