Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | LAP3 | P28838 | 5/20 | 0.51 |
| ▸ | ANPEP | P15144 | 3/20 | 0.51 |
| ▸ | RNPEP | Q9H4A4 | 3/20 | 0.51 |
| ▸ | DNPEP | Q9ULA0 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941281 | 0.80 | SMN1; SMN2 (0.46) | LAP3SMN1; SMN2HIF1AALPIPKM | |
| SCHEMBL8198281 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2HIF1A | |
| SCHEMBL7943084 | 0.74 | LAP3 (0.46) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL7959353 | 0.72 | ALPI (0.58) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL6321788 | 0.72 | ALPI (0.58) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL2029167 | 0.71 | ALPI (0.62) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL7436847 | 0.71 | ALPI (0.62) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL3841332 | 0.71 | ALPI (0.62) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL7415433 | 0.71 | ALPI (0.62) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL650855 | 0.71 | ALPI (0.62) | LAP3ANPEPRNPEPDNPEPLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019039937-A1 | THERAPEUTIC COMBINATION FOR CANCER TREATMENT | STICHTING VUMC (NL) | 2019-02-28 | — | — | WO | disclosed |
| WO-2009098451-A2 | BIOMARKERS OF AMINOPEPTIDASE INHIBITION | CHROMA THERAPEUTICS LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |