Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 2/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941284 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2HIF1ACYP1A2CYP2D6GRM2 | |
| Hydrochloric Acid SCHEMBL4023667 | 0.75 | LAP3 (0.51) | SMN1; SMN2HIF1A | |
| SCHEMBL13305755 | 0.74 | CYP2C19 (0.42) | HIF1ACYP1A2CYP2D6ADRA2AADRA2C | |
| SCHEMBL28498977 | 0.73 | KIF11 (0.40) | HIF1ACYP1A2CYP2D6GRM2GRM3 | |
| SCHEMBL15745582 | 0.72 | MAPT (0.44) | HIF1ACYP2D6ADRA2AADRA2CLMNA | |
| SCHEMBL13028672 | 0.72 | MAPT (0.44) | HIF1ACYP2D6ADRA2AADRA2CLMNA | |
| SCHEMBL16449781 | 0.72 | MAPT (0.44) | HIF1ACYP2D6ADRA2AADRA2CLMNA | |
| SCHEMBL3783637 | 0.70 | GRM2 (0.36) | GRM2GRM3 | |
| SCHEMBL13351981 | 0.70 | RIPK1 (0.50) | GRM2GRM3LMNA | |
| SCHEMBL31059197 | 0.70 | ALDH1A1 (0.53) | SMN1; SMN2HIF1ACYP1A2CYP2D6ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6033823-A | Mutated penicillin G acylase genes | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V., (NL) | 2000-03-07 | — | — | US | disclosed |
| EP-0775210-B1 | MUTATED PENICILLIN G ACYLASE GENES | DSM NV (NL) | 2000-02-02 | — | — | EP | disclosed |
| US-5935831-A | MUTATIONS IN AMINO ACID SEQUENCE OF ACYLASE RESULT IN ALTERATED SUBSTRATE SPECIFICITY; FOR ACYLATION OR DEACYLATION OF CEPHALOSPORIN AND PENICILLIN ANTIBIOTICS | GIST-BROCADES, N.V. (NL) | 1999-08-10 | — | — | US | disclosed |
| US-5891703-A | Mutated penicillin G acylase genes | GIST-HROCADES (NL) | 1999-04-06 | — | — | US | disclosed |
| EP-0453048-B1 | Mutated beta-lactam acylase genes | GIST BROCADES NV (NL) | 1998-06-17 | — | — | EP | disclosed |
| EP-0775210-A1 | MUTATED PENICILLIN G ACYLASE GENES | GIST-BROCADES B.V. (NL) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005318-A1 | MUTATED PENICILLIN G ACYLASE GENES | GIST-BROCADES B.V. (NL) | 1996-02-22 | — | — | WO | disclosed |
| US-5457032-A | Having altered substrate specificity | GIST-BROCADES NV (NL) | 1995-10-10 | — | — | US | disclosed |
| WO-1991016435-A1 | MUTATED BETA-LACTAM ACYLASE GENES | GIST-BROCADES N.V. (NL) | 1991-10-31 | — | — | WO | disclosed |
| EP-0453048-A1 | Mutated beta-lactam acylase genes | GIST-BROCADES N.V. (NL) | 1991-10-23 | — | — | EP | disclosed |