Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 15/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017413 | 0.86 | OPRD1 (0.49) | OPRK1OPRD1OPRM1CYP3A4CYP1A2 | |
| SCHEMBL4017837 | 0.82 | OPRK1 (0.40) | OPRK1OPRD1OPRM1CYP3A4CYP1A2 | |
| SCHEMBL4023184 | 0.80 | OPRK1 (0.42) | OPRK1OPRD1OPRM1 | |
| SCHEMBL4020717 | 0.80 | OPRK1 (0.52) | OPRK1OPRD1OPRM1 | |
| SCHEMBL4018608 | 0.80 | OPRK1 (0.43) | OPRK1OPRD1OPRM1 | |
| SCHEMBL4019000 | 0.79 | OPRK1 (0.45) | OPRK1OPRD1OPRM1SMN1; SMN2 | |
| SCHEMBL4019586 | 0.79 | OPRK1 (0.52) | OPRK1OPRD1OPRM1 | |
| SCHEMBL4016599 | 0.78 | OPRD1 (0.53) | OPRK1OPRD1OPRM1 | |
| SCHEMBL4023111 | 0.77 | OPRK1 (0.48) | OPRK1OPRD1OPRM1 | |
| SCHEMBL4022520 | 0.77 | OPRK1 (0.44) | OPRK1OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40838-E1 | 2-azabicyclo[3.3.1]nonane derivatives | PFIZER INC. (US) | 2009-07-07 | — | — | US | claimed |
| US-7056930-B2 | for treatment of disease states, disorders and conditions mediated by opioid receptors; for example, irritable bowel syndrome, drug addiction, including alcohol addiction, depression, anxiety, schizophrenia, eating disorders | PFIZER INC. (US) | 2006-06-06 | — | — | US | claimed |
| US-20040204445-A1 | 2-Azabicyclo[3.3.1]nonane derivatives | PFIZER INC. | 2004-10-14 | — | — | US | claimed |
| US-RE40838-E1 | 2-azabicyclo[3.3.1]nonane derivatives | PFIZER INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7056930-B2 | for treatment of disease states, disorders and conditions mediated by opioid receptors; for example, irritable bowel syndrome, drug addiction, including alcohol addiction, depression, anxiety, schizophrenia, eating disorders | PFIZER INC. (US) | 2006-06-06 | — | — | US | disclosed |
| US-20040204445-A1 | 2-Azabicyclo[3.3.1]nonane derivatives | PFIZER INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204445-A1 | 2-Azabicyclo[3.3.1]nonane derivatives | OPRD1, OPRK1, OPRM1 | OPRK1 2/4885OPRD1 1/4885OPRM1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.