Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | PTGIR | P43119 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15173773 | 0.81 | HCAR3 (0.38) | HCAR3HDAC1PTGDR2CXCR1CXCR2 | |
| SCHEMBL2790729 | 0.80 | HCAR3 (0.39) | HCAR3HDAC1TDP1ALDH1A1SYK | |
| SCHEMBL4172587 | 0.73 | HCAR3 (0.40) | HCAR3HDAC1PTGDR2POLBGRIN1 | |
| SCHEMBL3718183 | 0.73 | HDAC1 (0.37) | HCAR3HDAC1GRIN1GRIN2APTGIR | |
| SCHEMBL4782065 | 0.73 | HDAC1 (0.37) | HCAR3HDAC1GRIN2BCXCR1CXCR2 | |
| SCHEMBL13041524 | 0.73 | POLQ (0.49) | POLBAPEX1TDP1KDM4E | |
| SCHEMBL15551126 | 0.72 | POLQ (0.51) | POLBKMT2A | |
| SCHEMBL26508794 | 0.72 | TDO2 (0.49) | TDO2 | |
| SCHEMBL25436833 | 0.70 | JAK2 (0.34) | KMT2A | |
| SCHEMBL14547837 | 0.69 | TDO2 (0.36) | HDAC1PTGDR2TDO2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095712-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-06 | — | — | WO | disclosed |