Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782065 | 0.87 | HDAC1 (0.37) | HCAR3HDAC1ALDH1A1GRIN1GRIN2A | |
| SCHEMBL3718183 | 0.87 | HDAC1 (0.37) | HCAR3HDAC1TSHRALDH1A1GLA | |
| SCHEMBL6027792 | 0.78 | ALDH1A1 (0.45) | HTTTSHRALDH1A1GLAPOLB | |
| SCHEMBL1117875 | 0.78 | HCAR3 (0.48) | HCAR3HTTTSHRALDH1A1POLB | |
| SCHEMBL15173773 | 0.77 | HCAR3 (0.38) | HCAR3HDAC1GRM1PTGIRPTGDR2 | |
| SCHEMBL5508940 | 0.74 | POLB (0.60) | HTTTSHRALDH1A1GLAPOLB | |
| SCHEMBL4023870 | 0.73 | HCAR3 (0.39) | HCAR3HDAC1ALDH1A1GRIN1GRIN2A | |
| SCHEMBL4736030 | 0.72 | CACNA1H (0.47) | TSHRALDH1A1CACNA1HGBA1 | |
| SCHEMBL22518408 | 0.70 | TSHR (0.41) | HTTTSHRALDH1A1GLAPOLB | |
| SCHEMBL19714338 | 0.70 | PTGIR (0.52) | HTTHDAC1ALDH1A1PTGIRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009013545-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | WO | disclosed |
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |